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Kinase
A type of enzyme (a protein that speeds up chemical reactions in the body) that adds chemicals called phosphates to other molecules, such as sugars or proteins. This may cause other molecules in the cell to become either active or inactive. Kinases are a part of many cell processes. Some cancer treatments target certain kinases that are linked to cancer. [NCI]
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Kinase inhibitor
A substance that blocks a type of enzyme called a kinase. Human cells have many different kinases, and they help control important functions, such as cell signaling, metabolism, division, and survival. Certain kinases are more active in some types of cancer cells and blocking them may help keep the cancer cells from growing. Kinase inhibitors may also block the growth of new blood vessels that tumors need to grow. Some kinase inhibitors are used to treat cancer. [NCI]
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Knowledge Translation (KT)
A process of summarizing, distributing, sharing, and applying the knowledge developed by researchers to improve the health of the population, and strengthen the health care system through the use of more effective health services, products, and standards of practice. Integrated KT is a form of KT where researchers and knowledge users (e.g., policymakers, clinicians, patients) work together to determine research questions, decide on methodology, collect data, develop tools, interpret findings, and disseminate research results. This approach is intended to produce research findings that are more likely to be relevant to, and used by, the end users than studies designed and conducted by researchers alone. [CIHR] This may also be known as Knowledge Transfer and Exchange (KTE).
